There is a natural balance between free-radical formation and the defense system in both humans and animals. For a dairy cow to stay healthy the systems should stay in balance. But when the body is under stress, free radicals can get out of balance. When this system is out of balance, the body initiates an oxidative chain reaction, resulting in oxidative stress. Peroxidative damage can occur in lipids and macromolecules, which can cause free-radical formation. Those changes in cellular membranes can modify metabolic pathways with altered physiology and pathology, which can lead to decreased efficiency and premature cell death. Once critical structural damage occurs, antioxidants may no longer be able to repair the problems. Understanding proper balance could help reduce stress and prevent some of the greatest problems animals face — the same challenges that affect the dairy producer’s bottom line.